The Caleva Multi-Bowl Speronizer

The Caleva Lab Scale Multi-Bowl Spheronizer

 

General Description:

The Caleva Multi-Bowl Spheronizer has four different interchangeable spheronizer bowls which can be used on the same base to spheronize a wide range of batch sizes with a single apparatus. By using the appropriate bowls, it may be possible to process batches ranging in size from 1g to 1kg.

Spheronization is a batch process, and proper loading of the spheronizer drum is essential. Too little material, or too much material, can cause undesired agglomeration, excessive fines and will likely result in poor quality spheroids. The availability of different sized drums assures the formulator that she will have the proper sized drum to successfully process a given batch of material.

With a small diameter bowl the scientist can Work with small samples when product is scarce or costly. Then, by simply switching to a larger bowl, the formulator will have the ability to spheronize larger samples when when they become available, or when clinical trial quantities are required. The Multi-Bowl Spheronizer gives pharmaceutical R&D departments considerable flexibility when it comes to purchasing components: Have what you need when you need it; Upgrade in stages according to need.

Disks and inserts made of 316 stainless steel or FDA approved plastic are inserted into the 120mm bowl to acheive effective spheronization diameters of 60mm and 85mm.

The Multi-Bowl Spheronizer is designed for bench top use and is suitable for laboratory research and small batch production. It is a compact machine using limited amount of valuable bench space while at the same time is a powerful tool for both R&D and small scale production.

It has a simple operating structure. The front panel has "Start", "Stop" and "Emergency stop" buttons along with indicators for "Power on"and "Motor on." An electronic disc speed control is used for changing disc speed during spheronization. A digital readout gives the disc speed in RPM. The operator is protected from all moving parts by magnetic safety interlocks.

A drum heating/cooling jacket is included as standard on the 250mm bowl (optional for 120mm bowl) to allow processes to run at controlled temperatures. An optional water heating/cooling recirculating system can be suppled for more precise temperature control.

The 60 and 85mm inserts are available in 316 stainless steel or FDA approved plastic.

The Multi-Bowl Spheronizer has the the ideal capacity for scale up studies. It is robust in construction and will give you many years of trouble free use.

The optional Datastor™ package can be used to monitor and record operating parameters such as product temperature, disk speed power consumption. The data collected by the Datastor can be stored permanently.

Features:

• Bench-top spheronizer (marumerizer) for laboratory use designed for experimental work using small quantities of product, or small scale production using a larger bowl.
• Select the most appropriate sized bowl for the batch you are spheronizing.
• 60mm and 85mm diameter inserts made of 316 stainless steel and FDA approved plastics are available.
• Other types of disks, such as discs with a "radial " pattern (for a gentler spheronizing action) and disks with special coatings are available.
• Applications in the pharmaceutical, chemical, agricultural, and a wide variety of other applications.
• The Multi-Bowl Spheronizer is designed to work in conjunction with the Caleva Screen Extruder 20 and the Caleva Mini-Screw Extruder

Caleva Multi-Bowl Spheronizer

Specifications
Size (approx.):	50x30x52 cm.
Weight:	45 kg
Cabinet:	Grained 304SS
Contact Parts	316SS, food grade plastic and acrylic
Disk Speed	Between 0 and 1800 RPM.
Motor Power	180 W
Operational Requirements:	Front mounted panel with emergency stop, stop/start buttons, POWER ON, MOTOR ON indicators. A built-in digital tachometer shows disk rotation speed. Speed is set by an infinitely variable noncalibrated potentiometer. Electrical supply 115 VAC single phase or to customer's requirements.
Options:	250mm and 120mm drums/disks. 85mm and 60mm inserts for the 120mm bowl Jacketed drum for the 120mm spheronizer bowl, supplied with/without circulation system Automatic run timer Fines air (depending on configuration) PTFE coating on drum and discs Disks with spiral patterns Disks with different pitches Datastor Data Acquisition system
Production Capacity:	Inner Bowl Diameter Capacity 250mm 100g to 1kg 120mm 10g to 130g 85mm 5g to 15g 60mm 1g to 5g Batch size is volume limited and depends upon bulk density and characteristics of the material being spheronized. For pharmaceutical materials normally up to about 600g of material is spheronized as a single batch in the 250mm bowl. All figures approximate and for guidance only.