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Cronimo Production High Shear-Mixer Granulators

Cronimo High Shear Mixer Granulator for Pharmaceutical Production

Key Points
  • Ra. ≤ 0.2 µ Mirror Finished 316 Stainless Steel Processing Bowl, Inside and Out
  • Brushed 304 stainless steel on non-product contact surfaces
  • Free-Of-Paint Design
  • Choice of In-Wall or In-Room Configuration
  • Watson Marlow® Peristaltic Pump
  • Three Part Pneumatic Shaft Sealing System
  • High Torque Motors Driven by Inverters
  • Choice of manual, SoftLogic PLC-Based or SoftLogic TTM PC-Based Contols with True Torque Measurement™

Cronimo High-Shear Mixer Granulators for Pharmaceutical Manufacturing

 

General Description:

European Style Workmanship
at an Affordable Price

The CroNiMo production high shear granulators include the following bowl sizes: 25, 80, 125, 250, 400, 600 and 1000 liters. Each of these machines can be designed for in-room construction or “Thru-The-Wall” construction for either non-explosion or explosion proof rated environments. The control systems selected can be very simple standard PLC-based pushbutton controls to a fully automated system using either Allen Bradley or Siemens based controls including a touchscreen HMI. A fully automated system can be offered in full compliance with 21 CFR Part 11 and GAMP IV, including the required documentation. All production sized granulators have available as an option Cronimo TTM™ True Torque Measurement for end point detection.

All product contact parts as standard are constructed of 316 Stainless Steel and and polished to a #7 mirror finish with a surface roughness of Ra. < 0.20u. Non-product contact parts are 304 Stainless Steel with a #4 finish.

The CroNiMo high shear production granulators can be provided with a wide variety of mechanical options, such as bowl jackets, lighted bowl, liquid preparation system, heater/chiller units, vacuum loading, Stainless Steel filter housing and other features. One of the most popular options is an integrated cone mill attached directly to the granulator’s discharge valve.

Cronimo High Shear Mixer Granulators for Pharmaceutical Manufacturing with Their Dimensions and Production Capacities (See Figure Below)
Model 25 80 125 250 400 600 800 1000
  • Dimensions and weights provided in this table are approximate may be subject to change witout notice.
  • Options and final machine configuration must be specified during the URS recording phase of the project.
  1. Production capacities provided in this table are approximate. Actual working capacity depends on the material being processed.
Bowl(Gals.)
Volume1		 8 22 39 71 120 180 230 309
Working(Gals.)
Volume1		 6 17 26 60 101 156 200 273
Capacity(Lbs.)1 7-22 20-85 30-140 55-320 130-530 200-770 260-990 330-1320
Dimension A(Inches) 47 57 63 83 94 108 111 117
Dimension B 46 56 66 73 85 93 96 99
Dimension C 23 33 36 41 47 53 55 58
Dimension D 23 29 95 43 51 57 63 70
Dimension C(Inches)
w/Model UD
Cone Mill		 16 23 26 31 33 99 40 44
Cone Mill UD Model 3" 3" 5" 5" 8" 8" 8" 8"
Mixer Power(HP) 3.0 4.0 5.5 10.0 15.0 20.0 25.0 30.0
Mixer Speed(RPM) 27-202 22-166 21-157 19-136 16-123 15-114 13-100 10-80
Granulator(HP)
Power		 1.5 2.0 2.5 5.5 7.5 10.0 15.0 15.0
Chopper(RPM)
Speed		 1,000
to
3,400		 1,000
to
3,400		 1,000
to
3,400		 1,000
to
3,400		 1,000
to
3,400		 1,000
to
3,400		 1,000
to
3,400		 1,000
to
3,400
Weight(Pounds) 770 1,210 1,650 2,970 4,500 6,160 7,920 10,538

Outline image of Cronimo production granulator with overall dimensions for use with above table.

High Shear Granulator Options

The following is a list of options which is not intended to be limiting in any way. If you want something not on this list, just ask when we discuss your project.

  • Heating/Cooling Jacket
  • “Thru-The-Wall” Design
  • Liquid preparation/feed system
  • Working platform
  • Wash-In-Place (WIP)
  • Explosion-proof design
  • Pneumatic powder bowl loading
  • Validation document package
  • Mill and passivation certificates
  • TTM™ True Torque Measurement
  • Automated Controls Including:
    • Recipe based system
    • Historical trending
    • Real time trending
    • Alarm history
    • 21 CFR Part 11 Security
    • Batch event log
    • Printed reports
  • Heating/Chilling unit
  • Mill mounted on system
  • End Point Control via calculated 1st derivative of torque slope
  • Bowl lighting
  • Bowl sample port

 

 

 

 

Line drawing showing granulator in-wall configuration.

Granulator
In-Wall
Configuration

Line drawing showing granulator in-room configuration.

Granulator
In-Room
Configuration

 

 

 

 

 

 

 

 

 

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AC Compacting LLC
1577 Livingston Avenue, Post Office Box 7266
North Brunswick, NJ 08902-7266
Tel: 732-249-6900 / Tel: 800-524-0183 / Fax: 732-249-6909